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In this view, the imbalance between commensals and pathogens (namely dysbiosis) would enhance the entry of bacterial and food antigens into the systemic circulation, triggering auto-aggressive processes [180]

Leukocytes and other cells release arachidonic acid metabolites and platelet-activating factor (PAF) after activation of phospholipases by a variety of stimuli

In research models the two molecules act on parallel pathways of the growth hormone axis

Togo S, Holz O, Liu X, Sugiura H, Kamio K, Wang X, Kawasaki S, Ahn Y, Fredriksson K, Skold CM, Mueller KC, Branscheid D, Welker L, Watz H, Magnussen H, Rennard SI: Lung fibroblast repair functions in patients with chronic obstructive pulmonary disease are altered by multiple mechanisms