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Congress had passed a law in 1962 requiring the FDA to institute more rigorous testing for new drugs and to review the safety and efficacy of those already on the market

Oxidation, so as to ensure the normal performance of the physiological functions of molecules such as proteins and enzymes

Secondary OP is typically caused by underlying diseases and/or medication use, such as chronic conditions (e.g., cirrhosis, renal insufficiency, and malabsorption disorders) and drugs (e.g., anticonvulsants, heparin, thiazolidinediones, glucocorticoids, and immunosuppressants) (4, 5)

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