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In research models, any induced discomfort is managed by the study protocol

It is especially suited for patients dealing with neuropathic discomfort, stubborn inflammatory conditions, or post-injury nerve damage that hasn't responded to conventional approaches

Cross-compound receptor-occupancy percentages are deliberately not compared here: occupancy (pRO) is a modeled inference, not a measurement, and Willard 2020 cautions that "calculating pRO values has caveats." Binding affinity is the measured quantity

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