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Guttormsen AB, Ueland PM, Svarstad E, and Refsum H (1997)

Symptomatic treatment should be provided

Sandeep KP, Shukla SP, Vennila A, Purushothaman CS, Manjulekshmi N (2015) Cultivation of Spirulina (Arthrospira) platensis in low cost seawater based medium for extraction of value added pigments

When to Suspect APD APD should be suspected when: Skin symptoms recur monthly despite standard dermatologic treatment Symptoms reliably worsen before menstruation Reactions appear after starting progesterone or progestins Antihistamines provide partial but not complete relief Related: Histamine Intolerance: What It Is & What to Do About It APD Causes and Risk Factors APD develops due to an autoimmune response to progesterone, though the exact mechanism of this hypersensitivity is not fully understood