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sample size n= 562) study ( In a different but related context, another study investigated the impact of tobacco (smoke and extract) and shear stress on complement activation in human endothelial cells ( The decline in traditional smoking seems to have been associated with increased prevalence of novel tobacco products such as electronic/e-cigarettes, in part because of misconceptions regarding their safety ( in vitro in immortalized Kupffer cells, to determine their role as promoters of cardiovascular diseases through propagating the state of inflammation ( More recently, a study that examined the impact of e-cigarette extracts on platelets- which are major players in development of cardiovascular disease ( It is noteworthy that a study evaluated the combined effects of aging and cigarette smoking on stroke outcomes and the potential benefits of anti-complement mitigation strategies, in mice