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And it is interesting to note that the intrinsic pathway is mainly induced by blocking the expression or activity of intracellular phospholipid peroxide scavenging systems [e.g., glutathione peroxidase 4 (GPX4)], by excessive phospholipid peroxidation, or by a dysregulation of ferric ion homeostasis (194)

Data Submission and Reporting We are proposing that PCHs would be required to submit information for this measure once annually using a CMS-approved web-based data collection tool available within the Hospital Quality Reporting (HQR) System (previously referred to as the QualityNet Secure Portal) beginning with the FY 2026 program year

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