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Unfortunately, studies on this topic have mainly focused on normalising serum B12 concentrations with oral supplementation and should be interpreted with caution since the specific goal of treatment in symptomatic B12 deficiency is alleviating symptoms, and NOT to normalize B12 concentrations in the blood

Yes, this combination has been extensively studied in clinical trials under the name CagriSema

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When comparing the results of these studies, it is important to note that while Achilles tendons in females appear to be more protected from injury than males, females have an increased risk of ACL rupture, especially during menstruation (Arendt and Dick, 1995