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This participation contributes to the amplification and persistence of low-grade chronic inflammation within the joint cavity ( Furthermore, the complex intercellular communication network within the joint, involving exosomes and various cytokines secreted by synovial cells or chondrocytes themselves, also participates in the fine-tuning of ferroptosis susceptibility

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The overall design logic linking TME barriers, cross-cutting design objectives, nano-bio interface parameters, functional modules and representative strategy categories is summarized in Fig