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Trials and community sources report subjects consulting physicians or discontinuing upon experiencing sustained headaches, significant visual changes, or unusual swelling

[66] Since autism manifests in the early developmental period, sleep apnea in Down's Syndrome and other genetic syndromes such as Fragile X start early (at infancy or shortly after), and sleep disturbances alter brain development, [67] it's plausible that some of the neurodevelopmental differences seen in these genetic syndromes are at least partially caused by the effects of untreated sleep apnea

Nano Lett (2016) 16:54018

Long-term effects on insulin sensitivity remain under investigation