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Gel phase

ATM also phosphorylates multiple downstream targets (notably including, p53, -H2AX, CHK1 and CHK2) that are also involved in apoptosis, cell cycle regulation and DNA repair 47,48,49

10.1186/s13229-021-00472-4 49 EmanueleE.OrsiP.BosoM.BrogliaD.BrondinoN.BaraleF.et al (2010)

In addition to increasing the solubility of drugs and drug metabolites, the enzymes of phase II metabolism can limit bioactivity of a drug or toxicity of a drug metabolite