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Before obvious clinical symptoms appear in AD patients, increased BBB permeability occurs in many brain regions, including the hippocampus, cortex, deep gray matter, and white matter by Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) [146,147,148,149]

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B12 injections may be recommended for individuals with a deficiency of vitamin B12, which can cause symptoms such as fatigue, weakness, and anemia