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However, Bcl-2 and GSH interfere with two independent routes of viral replication cycle

[1] [6] g., 2 g twice daily)

Mechanistically, we found that the early pro-ferroptotic effect of dexamethasone, mediated through system Xcdependent impairment of GSH biosynthesis [7], was subsequently overridden by reduced iron availability at later time points

Building on this framework, this review synthesizes recent advancements in PCa-targeted therapeutics, encompassing molecular pathogenesis, contemporary pharmacologic agents, and innovative strategies, while providing a critical appraisal of persistent challenges and emerging countermeasures in this rapidly evolving field