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Acknowledgment The work in this study was supported by the Natural Science Foundation of China (grants 30971188, 81273279, 81302560, and 81373201)

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Microarray and RNA-sequencing studies have mapped its regulatory effect across approximately 4,000 human genes, including upregulation of VEGF, BDNF, and BMP-2 growth factors central to vascular, neural, and bone remodeling respectively