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Studies using constant light to decrease melatonin production show it causes Alzheimer s-like damage in the cells along with increasing the need for antioxidants such as SOD and monoamine oxidase.[ref] There have been quite a few recent studies and reviews pointing to the role of both low melatonin and circadian disruption in the accumulation of amyloid-beta plaque.[ref] So what are the results of human studies that have used long-term melatonin supplementation to prevent Alzheimers disease