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Sleep quality is also assessed by the Pittsburgh Sleep Quality Index (PSQI) questionnaire, which is widely used as a subjective assessment tool [142]

For example, IB kinase (IKK) promotes the ubiquitination of NRF2 by activating the phosphorylation of CYLD, which in turn inhibits CYLDs deubiquitination activity, further exacerbating oxidative stress damage in the kidneys of obesity-related nephropathy (ORN) [19]

Glutathione is a key component of cellular antioxidant defence mechanisms and aids in the reduction of oxidative stress

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