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Thus, these findings underscore the notion that translational mouse models replicate only a subset of human pathology, often readily show therapeutic effects, and lack the complexity of aged human tissues

Federico L, Haymaker C, Forget MA, Ravelli A, Bhatta A, Karpinets T, Zang R, Fang B, Zhang J, Wagner H, Bogatenkova E, Wistuba I, Sepesi B Heymach J, Gibbons D, Bernatchez C, Weissferdt A, Vaporciyan A, Futreal A, Zhang J, Lizee G, Talukder A, Roszik J, Tran H, Wagner H, Behrens C, Parra E, Caneles JR, Fujimoto J, Allison J Sharma P, Vence L, Roth J, Meraz I, Roarty E, Lacerda L, Byers L, &S, William Jr W