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This action causes macrophages to polarize towards an M1 phenotype and lymphocytes mount a cytotoxic T cell response to eliminate target cells 30

It appears to reverse cardiac damage by increasing blood vessel growth in injured tissues and activating a cardiac response that may promote healing of the cardiac tissue after an event of myocardial infarction

This observation, coupled with the added stability contributed by C-terminal amidation and the desire to increase the hydrophobicity of the peptide, led to the generation of a series of compounds with the structure N -acyl-Tyr-Ile-(6) amino-hexanoic amide