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150 Mast-cell-degranulation products, such as histamine, lipid mediators, and spingosine-1-phosphate, can activate immature DCs, trigger their mobilization to draining LNs, and induce the preferential priming of Th2 cells

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So when odor-causing stuff builds up inside your ducts (dust, mold, smoke residue, pet dander), the system spreads that smell everywhere

As North Carolina State Extension bluntly puts it, the bees have "found the perfect place to set up their hive and have no intention of leaving." Once the smoke clears, they are back to normal within minutes, often crankier than before