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In certain animal studies, its been found that IGF-1 may help protect against Parkinsons disease and induce clearance of brain amyloid-betas, which at high levels are associated with Alzheimers disease

However, it should not be ignored that natural small-molecule compounds may also cause kidney damage by inducing ferroptosis

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Therefore, we hypothesized that the excessive expression of GJs post-APAP exposure in hepsin / mice could be a key factor contributing to the increased severity of liver damage observed following APAP administration