Highly susceptible Car -/- C3H male mice initiated with diethylnitrosamine and promoted with phenobarbital do not develop liver tumors (Yamamoto et al
Interventional trials focusing on nutritional supplementation, while showing some benefits on NDD outcomes, often report effects that are modest, not statistically significant, and inconsistent [180, 197, 198, 203, 215]
Given the enhanced efficacy of the 5FU + metformin combination in AKP organoid models in 3D (Fig
Mier-Cabrera J, Aburto-Soto T, Burrola-Mendez S, Jimenez-Zamudio L, Tolentino M, Casanueva E, Hernandez-Guerrero C: Women with endometriosis improved their peripheral antioxidant markers after the application of a high antioxidant diet