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we also add that during depression, the activity of fundamental brain circuits is altered, as is documented by studies with brain images that have shown an expansion of the frontostriatal circuit of salience in depressed people [22]

Data including medical history, comorbidities calculated as CCIS, results of blood biomarkers, HRCT findings, treatment, and 12-week mortality were extracted from patients medical records 23

doi: 10.1210/jc.2002-021161 64 AzzamIGiladSLimorRSternNGreenmanY

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