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Due to the rate of the first observed event and the limitation imposed by mixing, all fits were extrapolated back to the artificially derived t zero absorbance

Iranian Journal of Pharmaceutical Research 18(3):14191428 Ahuja M, Ammal Kaidery N, Yang L, Calingasan N, Smirnova N, Gaisin A et al (2016) Distinct Nrf2 signaling mechanisms of fumaric acid esters and their role in neuroprotection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced experimental Parkinsons-like disease

The New England Journal of Medicines publication of the STEP trial revealed more than 50% of trial participants lost 15% of their body weight, and between 33-40% of participants lost 20% of their body weight