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Titration schedules in phase 3 trials of long acting insulin analogues incorporated individualization to allow the clinician to increase the dose to achieve optimal benefit without causing hypoglycaemia ( The oral obesity medications The oral GLP-1 based agents approved for obesity treatment deliver substantial weight loss

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Innovations in drug delivery systems, such as advanced nanocarriers and novel intrathecal formulations, are actively being explored to overcome the biodistribution and bioavailability barriers specific to the CNS, which are crucial for both biological therapeutics and small molecules (69)

Furthermore, the heterogeneity of RA and the absence of validated biomarkers complicate patient stratification and trial design, underscoring the need for tailored approaches to treatment