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Autophagy activation was observed to restore the mitochondrial membrane potential impaired by rotenone in SH-SY5Y cell lines overexpressing -synuclein [71] and attenuate rotenone-induced toxicity in SH-SY5Y cell lines [72]

For multi-level involvement, the systemic effects of TB-500 become even more valuable, as it supports healing throughout the body rather than at a single site