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One intriguing theory suggests that colonizing microglia are guided by a fractalkine gradient, which is sensed through the microglial fractalkine receptor, CX3CR1 (Mondo et al., 2020), which helps guide microglia along the developing vasculature

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Mass spectrometry was performed by LA at the Centre for Chemical Microscopy (ProVIS) at the Helmholtz Centre for Environmental Research, which is supported by European regional development funds (EFRE-Europe Funds Saxony) and the Helmholtz Association

Zonulin levels increased well before the onset of CIA 25 days post immunization (dpi) (Fig