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In contrast to earlier assumptions, this generation of protein adducts can take place before GSH levels are depleted extensively [15,23] and also after therapeutic doses of APAP without relevant GSH depletion [15,16]

Moreover, Org 24,598 administered prior to alcohol exposure (69 mg/kg, i.p.) over 7 days in rats resulted in reduced voluntary alcohol consumption (Olsson et al

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Some portion of intranasally administered peptides may reach the central nervous system through the olfactory pathway, bypassing the blood-brain barrier