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Phase I data presented at the American Heart Association (AHA) 2025 meeting and published in The New England Journal of Medicine ( NEJM ) showed deep, dose-dependent reductions in ANGPTL3 (up to 89%) with corresponding decreases in triglycerides and LDL cholesterol, including in patients already on standard lipid-lowering therapy

Preclinical studies have confirmed that targeted ferroptosis inhibition alleviates renal injury and fibrosis: 1) deferoxamine mitigates 5/6 nephrectomy-induced CKD in rats via iron metabolism and TGF-1/Smad3 pathway modulation (191)

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Desde el punto de vista cutneo, presentan diferentes efectos adversos (tabla III)53