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Insulin resistance fuels this process, worsening metabolic dysfunction, hyperglycemia, and lipid dysregulation, which further strain the cardiovascular, renal, hepatic, and metabolic systems (22, 23)

14 January 2026 A Correction to this paper has been published: References Griffiths CEM, Armstrong AW, Gudjonsson JE, Barker JNWN

To explore the functional significance of this interaction, we altered Lys59 of LET7 to aspartic acid (LET7(K59D)) and Gln440 to lysine (LET7(Q440K)), which individually disrupt the Lys59Gln440 hydrogen bond

Some individuals, particularly those with certain medical conditions or nutrient deficiencies, may have lower glutathione levels