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J Neuroimmunol 274:141148 Kalita J, Kumar V, Ranjan A, Misra UK (2015) Role of oxidative stress in the worsening of neurologic Wilson disease following chelating therapy

In some embodiments, the otic pharmaceutical formulation comprises about 50%, about 51%, about 52%, about 53%, about 54%, about 55%, about 56%, about 57%, about 58%, about 59%, about 60%, about 61%, about 62%, about 63%, about 64%, about 65%, about 66%, about 67%, about 68%, about 69%, about 70%, about 71%, about 72%, about 73%, about 74%, about 75%, about 76%, about 77%, about 78%, about 79%, about 80%, about 81%, about 82%, about 83%, about 84%, about 85%, about 86%, about 87%, about 88%, about 89%, about 90%, about 91%, about 92%, about 93%, about 94%, about 95%, about 96%, about 97%, about 98% , or about 99% by weight of the triglycerides

Concurrently, levels of testosterone synthesis-related proteins CYP11A1 and CYP17A1 were significantly decreased in these senescent cells