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The cause for that shift, like the subsequent trend to lower tar and nicotine cigarettes, lay with the mistaken notion that filtered and light cigarettes were safer than traditional ones

The local mucosal immune system has developed mechanisms for readily ignoring the harmless resident microflora and most of the inhaled/ingested substances (potential antigens/superantigens), while generating protective responses, such as locally produced immunoglobulins, especially IgA, to a wide range of pathogens

To date, no death has been reported that was attributable to the consumption of e-liquids containing nicotine