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Abstract Purpose This narrative review examines the role of essential nutritional factors in thyroid function, moving beyond the traditional focus on iodine supplementation

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In adult rodents, unilateral nephrectomy results in an early but transient rise in the expression of IGF-1 mRNA in the remaining kidney and a transient rise in systemic GH-concentrations, whereas IGF-1R levels in the kidney are unaffected [151,152,153]

Furthermore, ZZ-A1ATD patients exhibit altered levels of reactive species: a decrease in superoxide (O2-) and an increase in hydrogen peroxide (H2O2), peroxynitrite (ONOO-), and nitric oxide (NO) are observed