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Reservoir devices are optionally used with the pharmaceutical drug delivery units, and reside either internally along with the drug delivery unit, or externally of the auris structures

The full Thymosin Beta-4 molecule, under the name RGN-259, has entered formal clinical trials for conditions including dry eye disease and cardiac recovery, which validates the underlying biological mechanism that TB-500 shares

In other embodiments, the otic formulations or compositions described herein are administered as a controlled release formulation or compositions, released either continuously or in a pulsatile manner, or variants of both