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When combined, those risks are compounded in ways that cannot be predicted without rigorous clinical study

System Xc is an amino acid exchange system that transports extracellular cystine into the cell while exporting intracellular glutamate (32)

The control + DSS mice contained much lower abundance of known mouse commensal taxa and higher abundance of the Clostridium sensu stricto clade (54), which contains known pathogens such as Clostridium perfringens (55), and well-known butyrate-producing symbionts, such as Clostridium butyricum (46)