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These include modifying existing classification to conform with new information about the underlying mechanisms of diseases (e.g., mental illness), dealing with any still unknown causal structure and the complex causal structures behind diseases, investigating the similarities and differences between cases of disease, etc., as reviewed by Severinsen (2001), alongside a proposal of a pragmatic alternative and two pragmatic principles

The details of what specifically goes into these blends are only known to the Master Blenders

In reality of course, smoking is universally and extremely harmful for health

Orange peel in a Virginia blend might create interesting notes