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Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism

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chelation of the copper site by the thiol group, interference with the cellular transfer of tyrosinase to premelanosomes, which is the site of melanin synthesis and indirect inhibition of tyrosinase via its antioxidant effect as the free radical scavenging effect of it blocks the induction of tyrosinase activity caused by peroxides

We utilized site-directed mutagenesis of mouse GLRX in which one or multiple cysteines were mutated to serine (Supplementary Figs