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It is approved to reduce excess visceral fat in HIV-associated lipodystrophy , not for general weight loss or cosmetic fat reduction, and the effect reverses when treatment stops

doi: 10.1016/S0140-6736(09)60995-8 362 Vartak-SharmaN.GhorpadeA

In conclusion, various endogenous and exogenous pathophysiological mechanisms in patients with chronic kidney diseases lead to enhanced activity of oxidative enzymes such as xanthine oxidase (XO), myeloperoxidase (MPO), and the NADPH oxidase enzymes (NOX)

Antibiotic treatment in mice (which reduced the abundance of Bacteroidetes) also reduced the expression of tight junction protein mRNA expression in the hippocampus, but increased expression in the amygdala [150]