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The model structure is based on the PBPK compartment model reported by Aarons [23] where the remainder, heart, fat, muscle, brain, lungs, stomach, liver, portal vein, venous and arterial plasma, and red blood cells are defined as independent one compartment organs, while kidney and small intestine were developed as multicompartment organs to describe physiological processes by more detailed approach [23]

The EMBO journal 11:2503-2510

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