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It fails to develop a root apical meristem because the cells arrest at the G1 phase of the cell cycle (Vernoux et al., 2000)

D., Molden, D

Crit Care Med 24(3):392397 Fowler AA 3rd, Syed AA, Knowlson S, Sculthorpe R, Farthing D, DeWilde C, Farthing CA, Larus TL, Martin E, Brophy DF, Gupta S, Fisher BJ, Natarajan R (2014) Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis

Molecular analyses showed that CO23RFLC had acquired a marked increased expression of the MDR1 gene encoding for an efflux pump protein mainly responsible for the drug-resistance, due to a mutation in the transcription factor gene MRR1 [16] whereas CO23RFK had a homozygous mutation (S645Y substitution) in the FSK1 gene, responsible for the synthesis of glucan [17]