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The discussed studies were obtained from databases (PubMed, SciFinder), using the keyword Pycnogenol and placebo or double-blind. 2 Randomized, double-blind placebo-controlled human clinical studies with Pycnogenol The RDP human clinical studies conducted with Pycnogenol are summarized in Table 1, including a brief description of the study details and main findings

The increased levels of acetaldehyde in turn contribute to negative physiological effects that likely lead to behavioral effects that are associated with a reduced desire to consume alcohol

FTO level is upregulated in PD model, while FTO silencing alleviates cell ferroptosis