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One of the mechanisms of toxicity results from the fact that the main metabolic route by which ethanol is detoxified is via a series of two enzymes

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Infiltrating leukocytes such as tumor associated macrophages (TAMs), neutrophils, dendritic cells, and lymphocytes establish an inflammatory microenvironment and are key components in tumors of epithelial origins

Acknowledgements We sincerely thank Hua Hua, Anqi Zeng, Li Liu, Weiwei Tian, Ruirui Wang, Lei Zhang, and Junning Zhao for providing guidance and assistance on this paper