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For example, beta-carotene and vitamin C enhance iron absorption, while calcium and polyphenols appear to reduce the absorption of iron

This makes it particularly relevant in experimental models focused on targeted metabolic processes

In aged brains, the reduced expression of WIP1 in the aging brain is the result of the increased inhibition of Wnt signaling mediated through Dickkopf 3 (DKK3), a downstream target of WIP1 ( Fig