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Anticipate mixed results because of genetic and physiological variability

It is thus not surprising that targeting ROS has emerged as a potential therapy for hard-to-heal wounds, similar to other diseases, such as cancer 163,164 , neurodegenerative diseases 165 , T cell-mediated autoimmune diseases 166 , inflammatory skin diseases 167 , and others

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Interestingly, AMPK suppressed cell senescence and mouse aging by upregulating the expression of miR-708, which directly targets Dab2 and inhibits mTORC1 activity