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Fatal hypokalemia may occur when severe megaloblastic anemia is treated intensively with vitamin B12, as a result of increased erythrocyte potassium requirements

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We therefore introduced linear NHEJ substrates (Supplementary Dataset 1) into transformed mouse embryo fibroblasts (MEFs), under conditions where head-to-tail joining of substrate ends saturates at physiologically relevant levels (tens of repair products/cell) in a physiologically relevant amount of time (tens of minutes) (e.g., Fig

Definitive diagnosis is made by examination of liver biopsy specimens, with ancillary diagnostics providing supportive information