The delayed gastric emptying characteristic of these therapies frequently causes gastrointestinal adverse effects, particularly nausea, vomiting, and diarrhea
The mechanism behind oral efficacy is attributed to systemic absorption and downstream peptide signaling rather than localized delivery, though the exact bioavailability percentage in humans remains unquantified
3: Matek D, Matek I, Japjec M, Matek M, Prenc J, Staresinic B, Staresinic E, Prtoric A, Sikiric S, Beketic Oreskovic L, Oreskovic I, Strbe S, Kordic M, Tvrdeic A, Seiwerth S, Sikiric P, Boban Blagaic A, Skrtic A, Bojanic I, Dobric I, Staresinic M
It is referenced within academic and exploratory research environments due to its defined molecular structure and suitability for controlled experimental studies conducted in appropriate laboratory settings