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In normal individuals, a severe deficiency of thiamine (VitaminB1)will produce beriberi, a disease of diffuse symptoms associated with decreased activity of the 3 thiamine-dependent enzymes (pyruvate dehydrogenase, -ketoglutarate dehydrogenase, and transketolase)

Regarding the recent developments concerning the Wnt/-catenin pathway, the importance of the pathway in understanding different diseases is becoming the future direction for therapeutic research