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In summary, although IBD is a multifactorial disease in which activation of inflammatory cells is thought to play a key role for its development, the synergism between ROS generation and subsequent GSH depletion induced by TNBS appears to be a key event, at least in this model of acute colitis induced by TNBS+ethanol

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Hanania, EG, Giles RE, Kavanagh J, Ellerson D, Zu Z, Wang M, Su Y, Kudelka A, Rahman Z, Holmes F, Hortobagyi G, Claxton C, Vachier C, Thall P, Cheng S, Hester J, Ostrove J, Byrd R, Cheng A, Korbling M, Seong D, Cote R, Holzmayer T, Mechetner E, Heimfeld S, Berenson R, Burtness B, Edwards C, Bast R, Andreeff M , Champlin R, Deisseroth AB