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The dedicated cardiovascular trial did not find excess major events and reported lower all-cause mortality, but resting heart rate remains a titration marker rather than a one-time measurement. How to Titrate, and the Cost of Going Too Fast The final dose shapes the endpoint, but escalation speed is the largest modifiable driver of side effects

For 2026 review, the content emphasizes current verification, treatment fit, and patient-safety questions that can be discussed with a qualified provider

In severe cases, patients may experience long-term disability, reduced range of motion, or ongoing neurological symptoms