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Emerging evidence has indicated that branched ubiquitin chains, such as those containing mixed K11/K48 linkages, are pivotal in proteostasis, cell cycle progression and stress responses

EMBO J 23:48024812 de Keizer PL, Packer LM, Szypowska AA, Riedl-Polderman PE, van den Broek NJ, de Bruin A, Dansen TB, Marais R, Brenkman AB, Burgering BM (2010) Activation of forkhead box O transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence

Together, these systems help protect retinal cells and support lens clarity, helping maintain healthy vision over time