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It is characterized by initial reduced blood supply to tissues (ischemia) and subsequent reoxygenation via restored blood flow (reperfusion) ( 3.1.1 The specific role of the system Xc GSHGPX4 axis in I/R AKI System Xc , a key cellular antioxidant system, comprises two subunits (SLC7A11, the primary activity regulator, and SLC3A2) and localizes to the phospholipid bilayer

Instead, it works smarter modulating inflammatory cytokines and promoting resolution of inflammation at the source

Similarly, external supplementation with NAC restores cysteine level, which decreased during hypobaric hypoxia, eliminates endogenous hydrogen sulfide concentrations, and reduces neuronal dysfunction (195)