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Heterogeneous findings may be the product of cross-sectional designs with modest-to-moderate sample sizes, between-study variability in participant attributes (e.g., varying age ranges, smoking histories, sex ratios, or other sociodemographic characteristics), and/or methodological differences in MRI acquisition or data analysis parameters (e.g., smoothing, registration techniques, or normalization templates)

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And, as a result, more than 7,200 Louisiana adults die annually from illnesses caused by smoking